Stockholm3 test (STHLM3) is a blood test by means of which it is possible to assess the risk of prostate cancer better than with a mere PSA test and based on even lower PSA values (> 1 ng/ml), which reduces the number of prostate biopsies, i.e. tissue samples. If the STHLM3 test result is negative, a tissue sample need not necessarily be taken even if PSA was elevated (>3 ng/ml). Furthermore, STHLM3 is an efficient test for distinguishing between aggressive prostate cancer and more benign cancer.
The STHLM3 test combines information from five protein markers (total PSA, free PSA, hK2, MSMB and MIC-1), more than a hundred genetic tracers and clinical data (age, previous tissue samples, family history in prostate cancer, and, in some cases, an assessment of the structure and size of the prostate by a physician).
The tests are taken in cooperation with Karolinska University Hospital in Sweden, which is the developer of the test. The STHLM3 test has been assessed in a survey of almost 60,000 Swedish men, and the results have been published in the Lancet Oncology magazine in 2015 (Lancet 2015. Vol 16, no 16. p. 1667–1676).
Using the STHLM3 test
The STHLM3 test could replace the PSA test in all men aged 50–70. Furthermore, the STHLM3 test can be taken in cases when the PSA value is > 1.
STHLM3 is not suitable for men previously diagnosed with or cured of prostate cancer.
You can apply for the test directly from our appointments service. The test can be either the primary examination, if the PSA has not been measured, or it can be taken after the PSA test if PSA > 1.
How does the STHLM3 test work?
The STHLM3 test is a normal blood sample. The patient receives the test result from Karolinska Hospital. The result indicates the risk of prostate cancer on a risk scale—reduced, normal or elevated—and issues a clear recommendation for further examinations and/or follow-up.
Diagnostics develops continuously
The recommendations issued on the basis of the STHLM3 result may change as new research reveals more information.