Treatment of advanced prostate cancer
The key to treating patients with advanced prostate cancer is an individualized treatment program. The front-line treatment of metastatic prostate cancer always includes medical treatments , most commonly hormone therapy and chemotherapy, or a combination. If cancer has metastasized to the bones, a medication to strenghten them is often administered. Radiotherapy can be included in treatment with special techniques, even if there are extensive metastases.
If remission of prostate cancer is achieved by means of medical treatment, we at the Docrates Cancer Center always consider adding localized radiation therapy. This has been shown to be effective in the treatment of advanced prostate cancer. Irradiating of the prostate may also prevent urinary retention later on.
Hormonal treatments and chemotherapy can remain effective for long periods but usually lose their efficacy over time. In these situations, the second-line treatment of radionuclide therapy with a radioactive substance (radium or samarium) that targets the bones has been found to be both an effective and safe treatment option when metastases exist only in bone structures. Solitary, or a small number of, bone metastases can also be effectively treated with external radiotherapy if necessary. In addition to radium and samarium, new, experimental radioactive drugs, 177-lutetium-PSMA and 225-actinium-PSMA, have now been discovered. These might be an additional option, especially for elderly patients, for whom traditional chemotherapy may be challenging for example due to severe side effects.