Hodgkin lymphoma is a cancer of the lymphatic tissue. Usually, it starts in a lymph node and the first detected sign is an enlarged lymph node. Hodgkin lymphoma is most typically diagnosed in young adults. Today, its prognosis is good. Hodgkin lymphoma is classified into subcategories (classic and lymphocyte-predominant) by stage.

Risk of disease

The exact cause of Hodgkin lymphoma is not known. It is found more frequently than average in people with a disease that leads to immunodeficiency (such as AIDS) and people who are using medication that causes immunodeficiency (such as organ transplant medication). Epstein-Barr infection (mononucleosis) has been found to be a risk factor.

Symptoms

The only initial sign of Hodgkin lymphoma may be a swollen lymph node in the neck. Most patients are symptom-free at the time of diagnosis. The symptoms partly depend on the location of the tumor. A painless cough may be associated with the disease if mediastinal lymph nodes are enlarged. Some patients experience general symptoms, so-called ‘B’ symptoms, such as fever, sweating and tiredness.

Diagnosis

The disease is diagnosed by examining a piece of tissue, usually obtained by removing a swollen lymph node. Once the diagnosis is established, the cancer is staged. Usually, this involves a CT scan of the body and an FDG-PET/CT scan. A bone marrow biopsy may also be performed to ensure successful staging.

Treatment

The choice of treatment depends on the stage of disease and the symptoms. The most common treatments include chemotherapy and radiotherapy and combinations thereof. If the disease recurs, biological targeted agents may be used, and stem cell transplantation may be included in the treatment.

 

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